Gum disease is common and unpleasant, but, according to a growing body of evidence, it could also play a role in a surprising range of seemingly unrelated health problems. Cleaning your teeth may be even more important than you thought. Plaque — a sticky substance that contains bacteria — builds up on teeth. If it is not brushed away, the bacteria can irritate the gums.
The gums may then become swollen, sore, or infected; this is referred to as gingivitis. In general, gum disease can be treated or prevented by maintaining a good oral health regime. However, if it is left to develop, it can result in periodontitis, which weakens the supporting structures of the teeth.
Gum disease, which is also called periodontal disease, is widespread. According to the Centers for Disease Control and Prevention (CDC), almost half of adults in the United States have some degree of gum disease.
The mechanisms behind periodontal disease are relatively well-understood, and newer research shows that this health problem may play a role in the development of a number of other conditions, including Alzheimer’s disease, cancer, and respiratory disease. In this Spotlight, we will cover some of the surprising links between gum disease and disparate health issues.
Gums and the brain
Although spatially the gums are near the brain, one wouldn’t normally associate dental complaints with neurological conditions.
However, some studies have found a link between periodontal disease and tooth loss and cognitive function. One study looking at cognitive performance followed 597 men for up to 32 years. The authors conclude:
Risk of cognitive decline in older men increases as more teeth are lost. Periodontal disease and caries, major reasons for tooth loss, are also related to cognitive decline.
Researchers have also linked periodontal disease with an increased buildup of beta-amyloid in the brain — the neurological hallmark of Alzheimer’s.
Other experiments have produced evidence that one type of bacteria commonly found in cases of periodontitis — Porphyromonas gingivalis — can be found in the brains of individuals with Alzheimer’s.
Following on from that discovery, in a more recent study, researchers showed that P. gingivalis infection boosts the production of beta-amyloid in the brain.
Periodontal disease was associated with a small, but significant, increase in overall cancer risk.
In this study, the researchers paid particular attention to an enzyme produced by P. gingivalis called gingipain. They found that this protease was toxic to tau, another protein that plays a pivotal role in Alzheimer’s.
It is worth noting that other researchers have concluded that beta-amyloid is produced in response to a pathogen. The way we view Alzheimer’s is slowly changing.
In the future, scientists hope that targeting gingipain enzymes might help stop neurodegeneration in some people with Alzheimer’s disease. They have already designed a gingipain inhibitor, which they are testing in humans.
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1win es una plataforma de apuestas en linea reconocida por su compromiso de brindar a los jugadores una experiencia de juego unica y emocionante. Ya sea que te apasione el deporte, los juegos de casino o ambas opciones, 1win te ofrece una amplia gama de oportunidades para disfrutar y ganar.
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1win se destaca al ofrecer una amplia variedad de bonificaciones y promociones para satisfacer a jugadores de todas las preferencias:
Bonos de Bienvenida: Los nuevos jugadores son recibidos en 1win con un espectacular bono de bienvenida. Este bono se distribuye en los primeros cuatro depositos, lo que significa que tendras la oportunidad de aumentar significativamente tu saldo inicial. El bono de bienvenida puede alcanzar un impresionante 500% en total, con un limite de hasta 750 dolares.
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Torneos: Los torneos en 1win anaden emocion adicional a tu experiencia de juego. Participar en torneos te brinda la oportunidad de competir con otros jugadores por premios en efectivo y otros premios emocionantes. Los torneos pueden abarcar una variedad de juegos, desde tragamonedas hasta apuestas deportivas, y ofrecen una oportunidad adicional para ganar.
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Las bonificaciones en 1win ofrecen una oportunidad excepcional para aumentar tus ganancias y prolongar tu experiencia de juego en linea. Una de las bonificaciones mas destacadas es el emocionante bono de bienvenida:
Registrate en 1win y proporciona informacion precisa y completa.
Realiza tu primer deposito, ya que el bono se distribuye en los primeros cuatro depositos.
Reclama tu bono, que se acreditara automaticamente en tu cuenta.
Cumple con los requisitos de apuesta, que indican la cantidad de dinero que debes apostar antes de retirar las ganancias.
Explora y juega en una amplia gama de juegos, como tragamonedas o apuestas deportivas, para aumentar tus posibilidades de ganar.
El bono de bienvenida en 1win es una emocionante ventaja para comenzar tu experiencia de juego en linea. Sigue estos pasos y disfruta al maximo de tu bono en una de las principales plataformas de apuestas en linea de Mexico.
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Los codigos promocionales en 1win son una forma emocionante de aumentar tus oportunidades de ganar y aprovechar al maximo tu experiencia de juego. Estos codigos se pueden encontrar en varios lugares, lo que te brinda la posibilidad de desbloquear bonificaciones adicionales y ofertas exclusivas.
Muchos sitios web tematicos y portales dedicados a los juegos de azar ofrecen codigos promocionales de 1win. Estos codigos se actualizan regularmente y pueden proporcionarte bonificaciones unicas. Visita estos sitios y busca los codigos promocionales mas recientes.
Las redes sociales, como Facebook, Twitter e Instagram, son otra fuente donde puedes encontrar codigos promocionales. http://centroculturalrecoleta.org 1win a menudo publica codigos en sus perfiles sociales. Asegurate de seguir sus cuentas y estar atento a las publicaciones para no perderte ninguna oferta especial.
Si estas registrado en 1win y has aceptado recibir correos electronicos promocionales, es posible que recibas codigos promocionales exclusivos en tu bandeja de entrada. Estos codigos pueden ofrecer bonificaciones personalizadas segun tu historial de juego.
Una vez que tengas un codigo promocional, sigue estos sencillos pasos para activarlo:
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El uso de bonos y codigos promocionales en 1win ofrece una serie de beneficios que mejoran significativamente la experiencia de juego en linea:
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1win es una plataforma de apuestas en linea que ofrece una amplia variedad de opciones de apuestas deportivas y juegos de casino. La pagina web es facil de navegar y tiene un diseno moderno y atractivo. En cuanto a las apuestas deportivas, 1win ofrece una amplia variedad de deportes para apostar, desde los mas populares como el futbol y el baloncesto hasta deportes menos conocidos como el badminton y el rugby. Ademas, la plataforma ofrece una gran cantidad de mercados de apuestas para cada evento deportivo, lo que permite a los usuarios personalizar sus apuestas de acuerdo a sus preferencias. En cuanto a los juegos de casino, 1win ofrece una amplia variedad de opciones, desde tragamonedas hasta juegos de mesa como el blackjack y la ruleta. Los juegos son de alta calidad y estan disenados por algunos de los principales proveedores de software de casino. La plataforma tambien ofrece una amplia variedad de metodos de pago, incluyendo tarjetas de credito, billeteras electronicas y criptomonedas. Ademas, el sitio web esta disponible en varios idiomas, lo que lo hace accesible para usuarios de todo el mundo. En general, 1win es una plataforma de apuestas en linea solida y confiable que ofrece una amplia variedad de opciones de apuestas deportivas y juegos de casino.
Codigo promocional 1Win son canjeados desde su registro y utilizados en los juegos. Aplica el codigo 937999 y recibe ganancias al apostar. El codigo de promocion 2024 te regala un paquete de bienvenida del 500% con los cuatro primeros depositos hasta $700 en apuestas deportivas y casino. El codigo 1win de bono debe ser ingresado en el formulario de registro.
Si esta buscando una forma de maximizar sus ganancias en apuestas deportivas, no se pierda el codigo de promocion y el bono de bienvenida 1Win en 024]. Con el codigo de promocion 1Win puedes recibir ofertas exclusivas y apuestas gratis para disfrutar aun mas de tus juegos favoritos. Ademas, el bono de bienvenida 1Win es una gran oportunidad para aumentar sus ganancias y tener una experiencia de apuestas aun mas emocionante.
Bonificacion 1win – 937999
Como activo el vale en 1win?
Durante el proceso de registro se introduce un codigo promocional de la casa de apuestas 1win. El campo “Anadir codigo promocional” estara disponible para cualquier metodo de creacion de cuenta que elija. Tenga en cuenta que este campo es opcional en la fase de registro, asi que tenga cuidado al introducirlo. Si se olvida de hacerlo al registrarse, no podra activar su codigo en 1win y el bono de bienvenida dejara de estar disponible.
Tendras que recargar tu cuenta para poder utilizar el codigo promocional en el futuro. Una vez que haya introducido el codigo promocional durante el registro, vaya a su gabinete personal a traves del icono de usuario y haga clic en “Depositar”. Tomemos como ejemplo el codigo promocional “937999”, que corresponde a 200 euros.
Caracteristicas del bono 1win
El codigo promocional es proporcionado por representantes de la oficina de la casa de apuestas 1win. Lo hacen en varias ocasiones: durante una promocion, un dia festivo importante, el cumpleanos de un usuario, para volver a captar a un jugador que ha estado jugando durante un tiempo y ha dejado de estar activo.
Si introdujiste un codigo promocional al registrarte, veras los fondos de bonificacion en cuanto inicies sesion en tu perfil. Y si te lo dieron personalmente, deberas aceptar participar en la promocion para poder utilizarlo. Estos fondos se abonan en tu cuenta de bonificacion, y podras ver el importe en tu perfil personal. Si respeta las normas de uso de los fondos de bonificacion, podra convertirlos gradualmente en dinero en efectivo, que recibira ademas de sus ganancias.
?Que tan confiable es apostar en 1win?
Apostar en 1win es 100% confiable. 1win nacio en 2016, con el nombre de MFI Investments Limited, quienes estan registrados con el numero de licencia 8048/JAZ2018-040, otorgada por la Comision de Juegos eGaming.
Ademas, cuenta con alianzas comerciales con diferentes equipos y ligas, como la UEFA, UFC, NHL, FIFA y mas.
8. Opiniones 1win Casino 2024
1win casino es una excelente opcion para comenzar a apostar, ademas de que cuentas con el regalo para registrarte con el codigo promocional 937999. Podras tener tu cuenta abierta en todos lados, tu celular y tu computadora tendran tu cuenta sincronizada.
Es un sitio seguro, con numero de registro y sistemas de pago legales afiliados. Podras apostar con cualquier metodo de pago en mas de 50 deportes diferentes y cientos de juegos de casino. 1win es recomendable y esta lleno de diversion.
9. FAQ: 1win Codigo Promocional
9.1 ?? ?1win es un sitio seguro?
1win es un sitio seguro, esta avalado por la comision de juego eGaming. Sus metodos de pago son conocidos y de fiar, cada uno de ellos. Ademas, tambien de tener soporte tecnico las 24 horas ante cualquier duda.
9.2 ?? ?Hay bono de bienvenida de 1win?
Si existe, y para obtener este bono de bienvenida de 1win, necesitaras el codigo de bienvenida 937999, tendras que registrarte en 1win con este codigo y realizar tu primer deposito.
9.3 ?? ?Cual es el codigo de bono 1win?
El codigo promocional 1win es 937999, registrate y comienza a disfrutar de tu bono.
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